Publications

  1. Stevens, D.M.; Rahalkar, A.; Spears, B.; Gilmore, K.; Douglas, E.; Muthukumar, M.; Harth, E., “Semibranched polyglycidols as “fillers” in polycarbonate hydrogels to tune hydrophobic drug release.” Polymer Chemistry, 2015, DOI:10.1039/c4py00986jTOC Daid Hydrogel
  2. De la Croix Ndong, J.; Stevens, D.M.; Vignaux, G.; Uppuganti, S.; Perrien, D.; Yang, X.; Nyman, J.S.; Harth, E.; Elefteriou, F., “Combined MEK inhibition and BMP2 treatment promotes osteoblast differentiation and bone healing in Nf1oSX mice.” Journal of Bone and Mineral Research, 2014, accepted. http://onlinelibrary.wiley.com/doi/10.1002/jbmr.2316/abstractdoc1
  3. Holder, K.M.; Spears, B.R.; Huff, M.E.; Priolo, A.; Harth, E.; Grunlan, J. C. “Stretchable gas barrier achieved with partially hydrogen-bonded multilayer nanocoating.” Macromolecular Rapid Communications, 2014, 35(10), 960-964.  [article]doc2
  4. Stevens, D.M.; Gilmore, K.A.; Harth, E.”An assessment of nanosponges for intravenous and oral drug delivery of BCS class IV drugs: Drug delivery kinetics and solubilization.” Polymer Chemistry, 2014, 5, 3551-3554. (Paper of the Week, Polymer  Chemistry, RSC)  [article] doc3
  5. Hariri, G.; Edwards, A. D.;  Merrill, T.B.; Greenbaum, J.; van der Ende, A.E.; Harth, E.“Sequential targeted delivery of paclitaxel and camptothecin using a cross-linked “nanosponge” network for lung cancer chemotherapy.” Molecular Pharmaceutics, 2014, 11(1), 265-275.
    Sequentail Chemotherapy of Targeted Nanosponges
  6. Grove, K.; Dobish, J.; Harth, E.; Ingram, M.-C.; Galloway, R.L.; Mawn, L. “Trans-meningeal drug delivery to optic nerve ganglion cell axons using a nanoparticle drug delivery system.” Experimental Eye Research, 2014, 118, 42-45, Short Communication, DOI:10.1016/j.exer.2013.10.016; http://www.sciencedirect.com/science/journal/00144835/118
  7. Sapparapu, G.; Sims, A.L.; Aiyegbo, M.S.;  Shaikh, F.Y.; Harth, E.; Crowe, J.E. “Intracellular neutralization of a virus using a cell-penetrating molecular transporter.” Nanomedicine, 2014, Vol 9, No.11, 1613-1624, DOI:10.2217/nnm.13.139; http://www.futuremedicine.com/toc/nnm/9/11

Treatment of Viral Infections

  1. Chinessa T. Adkins, Julia N. Dobish, Scott Brown, and Eva Harth, “Water-soluble semiconducting nanoparticles for Imaging.” ACS Macro Lett., 2013, 2 (8), 710-714. DOI: 10.1021/mz400370f

        ACS Macro 2013
  2. Spears, B.R.; Waksal, McQuade, C.; Lanier,L.; and Harth, E.“Controlled branching of polyglycidol and formation of protein–glycidol bioconjugates via a graft-from approach with “PEG-like” arms.” Chemical Communication, 2013, 49, 2394-2396.
    ChemComm Cover       Chem. Commun. 2013
  3. Stevens, D.; Watson, H.; LeBlanc, M.A.; Wang, R.; Chou, J.; Bauer, W.; Harth, E.“Practical polymerization of functionalized lactones and carbonates with Sn(OTf)2 in metal catalysed ring-opening polymerization methods.” Polymer Chemistry, 2013, 4, 2470-2474.
    Polym. Chem. 2013
  4. Stevens, D.M.; Tempelaar, S.; Dove, A.; Harth, E. “Nanosponge formation from organocatalytically synthesized poly(carbonate) copolymers.” ACS MacroLetters, 2012, 1(7), 915-918.
    ACS Macro Letters
  5. Dobish, J.N.; Hamilton, S.K.; Harth, E. “Synthesis of low-temperature cross-linker and utilization.” Polymer Chemistry, 2012, 3(4), 857-860.
    illustration
  6. Chinessa T. Adkins Julia N. Dobish, Clifford S. Brown, Brian Mayrsohn, Sharon K. Hamilton, Felicia Udoji, Kelly Radford, Thomas Yankeelov, John C. Gore and Eva Harth “High relaxivity MRI imaging reagents from bimodal star polymers.” Polym. Chem., 2012, 3, 390-398. DOI: 10.1039/C1PY00474C, Paper
    illustration
  7. Hamilton, S.K.; Sims, A.L.; Donovan, J.; Harth, E. “Non-viral siRNA delivery vectors: Dendritic molecular transporter and molecular transporter nanovectors for target gene silencing.” Polymer Chemistry, 2011, 2(2), 441-446 (Emerging Investigator issue)
    pub_Poly Chem RSC
  8. Van der Ende, Alice E.; Harrell, J.; Sathiyakumar, V.; Mischievitz, M.; Katz, J.; Adcock, K.; Harth E.* ““Click” Reactions: Novel Chemistries for the Synthesis of Polyester Nanoparticles.” Macromolecules, 2010, 43 (13), 5665-5671.†
    † top seventh most read article in June 2010 (listed are top twenty)

    macromolecules
  9. Passarella, R. J.; Spratt, D.E; van der Ende, A.E.; Phillips, J.G.; Wu, H.; Sathiyakumar, V.; Zhou, L.; Hallahan, D.E.; Harth, E.; Diaz, R. “Targeted delivery systems with a sustained release.” Cancer Research, 2010, 70, 4550-4559. Highlighted by the National Cancer Institute (NCI) Alliance for Nanotechnology in Cancer website, July 14, 2010. http://nano.cancer.gov/action/news/2010/jul/nanotech_news_2010-07-14b.asp nanoparticle-news
  10. Van der Ende, A.; Sathiyakumar, V.; Diaz, R.; Hallahan, D.E.; Harth, E. “Linear release nanoparticle devices for advanced targeted cancer therapies with increased efficacy.” Polymer Chemistry, 2010, 1, 93-96.
  11. Adkins, C.T.; Muchalski, H.; Harth, E. “Nanoparticles with individual site-isolated semiconducting polymers from intramolecular chain collapse processes.” Macromolecules, 2009, 42 (15), 5786-5792.
  12. Hamilton, S.K.; Harth, E. “Molecular Dendritic Transporter Nanoparticle Vectors Provide Efficient Intracellualar Delivery of Peptides.” ACS Nano, 2009, 3 (2), 402-410.
  13. Van der Ende, A.; Croce, T.; Hamilton, K.; Sathiyakumar, V.; Harth, E. “Tailored Polyester Nanoparticles: Post-Modification with Dendritic Transporter and Targeting Units via Reductive Amination and Thiol-ene Chemistry.” Soft Matter2009, 5, 1417-1425.
  14. Hamilton, S.K.; Ikizler, M.R.; Wallen, C; Wright, P.F.; Harth, E. “Effective Delivery of IgG antibodies into infected cells via IgGMT conjugate.” Molecular Biosystems, 2008, 4, 1209-1211. (Article highlighted in Chemical Biology, RSC)
  15. Van der Ende, A.E.; Kravitz, E.J.; Harth E. “Approach to Formation of Multifunctional Polyester Particles in Controlled Nanoscopic Dimensions.” Journal of the American Chemical Society, 2008, 130, 8706-8713. PDF
  16. Adkins, C.T.; Harth, E. “Synthesis of Star Polymer Architectures with Site-Isolated Chomophore Cores.” Macromolecules, 2008, 41(10); 3472-3480. PDF
  17. Somarajan, S.; Hasan, S.A.; Adkins, C.T.; Harth, E.; Dickerson, J.H. “Controlled Electrophoretic Deposition of Uniquely Nanostructured Star Polymer Films.” Journal of Physical Chemistry B, 2008, 112(1), 23-28.
  18. Huang, K.; Croce, T.A.; Hamilton, S.K.; Adkins, C.T.; Evans, B.L. III.; Harth, E. “”Effective Drug Therapies from Functional, Macromolecular Building Blocks with a Biomimetic Design.” Macromol. Symp. 2007, 255, 20-23.
  19. Croce, T., Hamilton, S.K., Chen, M.L., Muchalski, H., Harth, E., “Alternative o-chinodimethane crosslinking precursors for intramolecular chain collapse nanoparticles.” Macromolecules, 2007, 40(17),6028-6031.
  20. Huang, K., Voss, B., E., Kumar, D., Hamm, H. E., Harth, E., “Highly targeted intracellular delivery: Tailored dendritic molecular transporter.” Bioconjugate Chemistry, 2007, 18, 403-409.
  21. Harth, E., Croce, T.A., “Carving out niches for nanostructures: Implementation and interplay of building blocks, methods and tools.” Australian Journal of Chemistry, 2006, 59, 525-533.
  22. Chung, I.D.; Britt, P.; Xie, D.; Harth, E.; Mays, J.,” Synthesis of amino acid-based polymers viaatom transfer radical polymerization in aqueous media at ambient temperature.” Chemical Communication, 2005, 1046.
  23. Drockenmuller, E.; Li, L.Y.T.; Ryu, D. Y.; Harth, E.; Russell, T.P.; Kim, H.C.; Hawker, C.J. “Covalent Stabilization of Nanostructures: Robust Block Copolymer Templates from Novel Thermoactive Systems.” Journal of Polymer Science Part A – Polymer Chemistry. 2005, 43, 1028.
  24. Götz, H.; Harth, E.; Schiller, S.M.; Frank, C. W.; Knoll, W.; Hawker, C.J., “Synthesis of lipo-glycopolymer amphiphiles by nitroxide-mediated living free-radical polymerization” Journal of Polymer Science Part A-Polymer Chemistry, 2002, 40, 3379.
  25. Harth, E.; Van Horn, B.; Lee, V.Y.; Germack, D.S.; Gonzales, C.P.; Miller, R.D.; Hawker, C.J. “A facile approach to architecturally defined nanoparticles via intramolecular chain collapse.” Journal of the American Chemical Society 2002, 124, 8653.
  26. Blomberg, S.; Ostberg, S.; Harth, E.; Bosman, A.W.; Van Horn, B.; Hawker, C.J,” Production of crosslinked, hollow nanoparticles by surface-initiated living free-radical polymerizatio”n Journal of Polymer Science Part A-Polymer Chemistry, 2002, 40, 1309.
  27. Harth, E.; Hecht, S.; Helms, B.A.; Malmstrom, E.E.; Fréchet, J.M.J.; Hawker, C.J. “The effect of macromolecular architecture in nanomaterials: A comparison of site isolation in phorphyrin core dendrimers and their isomeric linear analogs.” Journal of the American Chemical Society, 2002, 124, 3926.
  28. Hawker, C.J.; Bosman, A.W.; Harth, E.; “New polymer synthesis by nitroxide mediated living radical polymerizations.”Chemical Reviews, 2001, 101, 3661.
  29. Harth, E.; Bosman, A.W.; Benoit, D.; Helms, B.;  Fréchet, J.M.J.; Hawker, C.J. “A practical approach to the living polymerization of functional monomers: Application to block copolymers and 3-dimensional macromolecular architectures.”Macromolecular Symposium 2001, 174, 85.
  30. Harth, E.; Hawker, C.J.; Fan, W.; Waymouth, R.M. “Chain end functionalization in nitroxide-mediated free radical polymerizations.” Macromolecules. 2001, 34, 3856.
  31. Harth, E.; Van Horn, B.; Hawker, C.J. “Acceleration in nitroxide mediated ‘living’ free radical polymerizations.” Chemical Communications. 2001, 9, 823.
  32. Rodlert, M.; Harth, E.; Rees, I.; Hawker, C.J. “End-group fidelity in nitroxide-mediated living free radical polymerizations”Journal of Polymer Science Part A-Polymer Chemistry, 2000, 38, 4749.
  33. Benoit, D.; Harth, E.; Fox, P.; Waymouth R.M.; Hawker C.J. “Accurate structural control and block formation in the living polymerization of 1,3-dienes by nitroxide-mediated procedures” Macromolecules, 2000, 33, 363.
  34. Schubert, U.S.; Weidl, C.H.; Cattani, C.; Eschbaumer, C.; Newcome, G.R.; He, E.; Harth, E.; Mullen, K.; “Metallosupramolecular-fullerene assemblies and polymers”, Polym. Prep, 2000, 41(1), 229.
  35. Schubert, U.S.; Weidl, C.H.; Rapta, P.; Harth, E.; Mullen, K.; “Metallo-supramolecular fullerene architectures: Synthesis and characterization of bucky ligands and a non-covalent dimer.” Chemistry Letters, 1999, 9, 949.
  36. Kallinger, C.; Hauder, M.; Haugeneder, A.; Lemmer, U.; Spirkl, W.; Feldmann, J.; Scherf, U.; Harth, E.; Gugel, A.; Mullen, K. “Control of electron transfer in conjugated polymer fullerene heterostructures” Synthetic Metals, 1999, 101(1-3), 285.
  37. Hong, H.; Davidov, D.; Kallinger, C.; Lemmer, U.; Feldmann, J.; Harth, E.; Gugel, A.; Mullen, K. “Self-assembly of functionalized fullerenes.” Synthetic Metals, 1999, 102(1-3), 1487.
  38. Haugeneder, A.; Neges, M.; Kallinger, C.; Spirkl, W.; Lemmer, U.; Feldmann, J.; Scherf, U.; Harth, E.; Gugel, A.; Mullen, K. “Exiton diffusion and dissociation in conjugated fullerene blends and heterostructures.” Physical Review B-Condensed Matter 1999, 59 (23), 15346.
  39. Kocher, M.; Daubler, T.K.; Harth, E.; Scherf, U.; Gugel, A.; Neher, D. “Photoconductivity of an inorganic/organic composite containing dye-sensitized nanocrystalline titanium dioxide.” Applied Physical Letters, 1998, 72(6), 650.
  40. Kallinger,C.; Haugeneder, A.; Lemmer, U.; Feldmann, J.; Hong H.; Tarabia, M.; Daviov, D.; Harth, E.; Walter, M.; Scherf, U.; Gugel, A.; Mullen, K., in Molecular Nanostructures, edited by Kuzmany, H.; Fink, J.; Mehring, M.; Roth, S.; (World Scientific, Singnapore, 1997), 515.
  41. Gugel, A.; Belik, P.; Walter, M.; Kraus, A.; Harth, E.; Wagner, M.; Spickermann, J.; Mullen, K. “The repetitive Diels-Alder reaction: A new approach to [60]fullerene main-chain polymers.” Tetrahedron 1996, 52(14), 5007.
  42. Jonas, U.; Cardullo, F.; Belik, P.; Diederich F.; Gugel, A.; Harth, E.; Herrmann, A.; Isaacs, L.; Mullen, K.; Ringsdorf, H.; Thilgen, C.; Uhlmann, P.; Vasella, A.; Waldraff, C.A.A.; Walter, M. “Synthesis of a fullerene[60] cryptate and systematic Langmuir-Blodgett and thin-film investigations of amphiphilic fullerene derivatives.” Chemistry-A European Journal, 1995, 1(4), 243.
  43. Uhlmann, P.; Harth, E.; Naughton, A.B.; Vasella A. “Glycosylidene carbenes 20: Synthesis of deprotected, spiro-linked C-Glycosides of C-60.” Helvetica Chimica Acta 1994, 77(8), 2335.